For an oocyte to get Completely ready for fertilization and growth into an embryo, the proper list of genes really should be turned on. Namekawa suspected that this pre-programming with the oocyte genome occurs in numerous phases — the first one starting around the time a woman is born. He thought that chromatin remodeling proteins did A great deal of this function, by shifting spools all around.
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Using the GCRLE grant, Munakata and Namekawa will look additional carefully at how oocytes are genomically primed and stored for later use. They will examine the function of a chromatin remodeler in oocyte survival and fertility.
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